| Specific approvals vary with
jurisdiction. The appropriate governmental agency should be
consulted if in doubt about approved indications. GluStitch
inc. will not be held responsible for "off label use." In
Canada Glustitch® has been approved for topical use on broken
skin. |
 |
| Ayton J |
| Polar Hands: Spontaneous Skin Fissures Closed
With Cyanoacrylate (Histoacryl Blue) Tissue Adhesive in Antarctica |
| Arctic Medical Research (1993) 52:127-130 |
A series of thirteen
patients with "polar
hands", painful fissuring of fingertips, is documented
in Antarctic medical practice together with the results of
treatment by cyanoacrylate (Histoacryl Blue) human tissue adhesive.
Reduction in tenderness and pain allowing improved finger function
and a quicker resolution was observed. Cyanoacrylates are useful
adjuncts in the treatment of painful cracks and fissures.
|
| |
| Quinn J and Kissick J |
| Tissue Adhesives for Laceration Repair During
Sporting Events |
| Clinical Journal of Sport Medicine (1994) 4:245-248 |
Physicians covering sporting events are often
required to repair lacerations. Traditionally these lacerations
have been sutured. Some of these lacerations may be closed
with a tissue adhesive. Tissue adhesives have been available
for many years. The benefits and potential problems of these
substances are discussed as well as proper wound selection
and application.
|
|
| Craven M and Telfer N |
| An Open Study of Tissue Adhesive in Full-thickness
Skin Grafting |
| Journal of the American Academy of Dermatology
(1999) 40:604-611 |
» Background:
Securing full-thickness skin grafts (FTSG) by suturing
is a time-consuming procedure, even in experienced
hands. The advent of tissue adhesives has led to their use
in a variety of surgical procedures, providing an acceptable
alternative to conventional suturing.
» Objectives: Our purpose was to identify whether the tissue adhesive n-butyl-2-cyanoacrylate
(NBCA) can be used to secure FTSG and to compare to outcome with the conventional
suturing.
» Methods: Twenty-one patients with defects after
Mohs micrographic surgery were enrolled into the study. An
initial pilot study of 8 patients compared
NBCA and
sutures within individual grafts: the subsequent 13 patients had grafts
secured with between 4 and 8 cardinal sutures and NBCA alone.
» Results: No differences in healing, complications,
or cosmetic appearance were observed between the sides secured
with NBCA and with sutures in the
pilot study.
Of the grafts in the subsequent 13 patients, 2 patients experienced superficial
necrosis with subsequent healing and a good cosmetic outcome, the remainder
healed in place without complications, with excellent cosmetic outcome.
» Conclusion: NBCA is
suitable for securing selected FTSG and provides a significant
timesaving over the traditional approach of suturing
such grafts into place.
|
|
| Osmond M et al |
| A Randomized, Clinical Trial Comparing Butylcyanoacrylate
With Octylcyanoacrylate in the Management of Selected Pediatric
Facial Lacerations |
| Academic Emergency Medicine (1999) 6:171-177 |
» Objective: To compare
two tissue adhesives, butylcyanoacrylate and octylcyanoacrylate,
in the treatment of small (<4 cm)
superficial linear traumatic facial lacerations in children.
» Methods: This was a randomized, clinical trial with parallel design. 94 children
18 years of age seen in the ED of tertiary care pediatric hospital with a facial
laceration suitable for tissue adhesive closure underwent laceration closure
using either butylcyanoacrylate or octylcyanoacrylate. The primary outcome was
the cosmetic result at three months rated from photographs by a plastic surgeon
on a visual analog scale (VAS). Secondary outcomes included the time to procedure,
the pain perceived difficulty by the patient, and wound evaluation score at ten
to 14 days and three months.
» Results: Ninety-four patients were randomized with 47 in each group. The two
groups were similar for baseline demographic and clinical characteristics. There
was no differences in the three-month cosmesis VAS (median, 70.0 mm for n-butyl-2-cyanoacrylate
vs 67.5mm for octylcyanoacrylate, p = 0.84). There was no difference between
the groups for time to complete the procedure (p = 0.88), parent/patient-perceived
pain of the procedure 9p =0.37), or physician-perceived difficulty of the procedure
(p=0.33). Similarly, there was no difference difference between the groups for
the percentage of early (p =0.58) or late (p = 0.71) optimal wound evaluation
scores.
» Conclusions: In the closure of small linear pediatric facial lacerations, octylcyanoacrylate
is similar to butylcyanoacrylate in ease of use and early and late cosmetic outcomes.
The superior physical properties of octylcyanoacrylate appear to add little benefit
to the management of these selected lacerations. Physician preference and differing
costs may dictate use for these small selected lacerations.
|
|
| Rivers J.K. |
| N-2-butylcyanoacrylate
(GluStitch®) |
| Skin Therapy Letter Vol. 4 No. 5 |
Cyanoacrylates are surgical adhesives that provide
another option for wound closure. When compared to sutures,
cyanoacrylates were found to be as effective as sutures inlow
tension lacerations and for the attachment of some full-thickness
skin grafts. In addition, clinical practitioners have found
cyanoacrylates easier to apply, time saving, and more economical.
there are a number of surgical adhesives either currently or
under development. The presently vailable butylcyanoacrylates
and octylcyanoacrylates are reviewed.
|
| Clinical Practice |
| The Use Of Cyanoacrylates In Periodontal Therapy |
| Jim Grisdale, BA, DDS, Dip. Prosth., Dip. Perio.,
MRCD |
| N-butyl cyanoacrylate is an effective tissue
adhesive which is hemostatic and bacteriostatic. It can be
considered an alternative to conventional sutures in soft-tissue
surgery. The author presents two cases demonstrating the use
of the material. Case One shows its use if free gingival graft
surgery. Case Two shows it use post-biopsy.
MeSH Key Words: cyanoacrylates/therapeutic use; periodontal
dressings; tissue adhesives.
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